Seminar of the School of Physical Sciences
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Title: Role of Special Cross-links in Structure Formation of Bacterial DNA Polymer
Speaker: Apratim Chatterjee (IISER-Pune)
Date: January 16, 2018 (Tuesday)
Time: 16:00 hrs (4:00 pm)
Venue: Seminar Room, First Floor, School of Physical Sciences (SPS), JNU
Abstract: In-vivo DNA organization at large length scales (∼100nm) is highly debated and polymer models have proved useful to understand the principle of DNA-organization. Here, we show that less than 2% cross-links at specific points in a ring polymer can lead to a distinct spatial organization of the polymer. The specific pairs of cross-linked monomers were extracted from contact maps of bacterial DNA. We are able to predict the structure of 2 DNA-polymers using Monte Carlo simulations of the bead-spring polymer with cross-links at these special positions. Simulations with cross-links at random positions along the chain show that the organization of the polymer is different in nature from the previous case.