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SCMM organises a seminar by Mariko Okada

SCMM organises a seminar by Mariko Okada

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SCMM organises a seminar by Mariko Okada
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SPECIAL CENTRE FOR MOLECULAR MEDICINE

JAWAHARLAL NEHRU UNIVERSITY

 

Seminar on

 

Systems biology of signaling network

 

by

Mariko Okada

Professor & Head, Laboratory of Cell Institute for Protein Research,

Osaka University, Osaka, Japan

 

Date: 7th March 2018, Time: 11.00 am

Venue: Seminar Room, SCMM, JNU, New Delhi

 

Cells respond to external stimuli and eventually make their decision for survival, growth and differentiation. In this process, the activities of signal transduction network and downstream transcription factors show dynamically rich, nonlinear behaviors. In cancer systems, this signal transduction network is often dysregulated by overexpression and mutation of genes in the network. To understand the relationship between the dynamics of signaling pathways and cell commitment, we analyze the network using mathematical modeling approaches. Our analysis indicated that there are several common rules to control cellular proliferation and differentiation. In particular, we identified threshold mechanisms for transcription factor activation which can possibly alter the cellular states digitally. In this seminar, I will introduce our modeling approaches for NF-κB signaling and ErbB receptor signaling network in immune and cancer cells, respectively.

 

Reference

Magi et al. (2017) J. Biol. Chem. 2017

Magi et al. (2017) Current Opinion in Systems Biology. 2:38-47

Inoue et al. (2016) NPJ Syst. Biol. Appl. 2, 16024

Shinohara et al. (2014) Science. 344(6185):760-764

Nakakuki et al. (2010) Cell. 141(5):884-896

 

All are welcome

A warm welcome to the modified and updated website of the Centre for East Asian Studies. The East Asian region has been at the forefront of several path-breaking changes since 1970s beginning with the redefining the development architecture with its State-led development model besides emerging as a major region in the global politics and a key hub of the sophisticated technologies. The Centre is one of the thirteen Centres of the School of International Studies, Jawaharlal Nehru University, New Delhi that provides a holistic understanding of the region.

Initially, established as a Centre for Chinese and Japanese Studies, it subsequently grew to include Korean Studies as well. At present there are eight faculty members in the Centre. Several distinguished faculty who have now retired include the late Prof. Gargi Dutt, Prof. P.A.N. Murthy, Prof. G.P. Deshpande, Dr. Nranarayan Das, Prof. R.R. Krishnan and Prof. K.V. Kesavan. Besides, Dr. Madhu Bhalla served at the Centre in Chinese Studies Programme during 1994-2006. In addition, Ms. Kamlesh Jain and Dr. M. M. Kunju served the Centre as the Documentation Officers in Chinese and Japanese Studies respectively.

The academic curriculum covers both modern and contemporary facets of East Asia as each scholar specializes in an area of his/her interest in the region. The integrated course involves two semesters of classes at the M. Phil programme and a dissertation for the M. Phil and a thesis for Ph. D programme respectively. The central objective is to impart an interdisciplinary knowledge and understanding of history, foreign policy, government and politics, society and culture and political economy of the respective areas. Students can explore new and emerging themes such as East Asian regionalism, the evolving East Asian Community, the rise of China, resurgence of Japan and the prospects for reunification of the Korean peninsula. Additionally, the Centre lays great emphasis on the building of language skills. The background of scholars includes mostly from the social science disciplines; History, Political Science, Economics, Sociology, International Relations and language.

Several students of the centre have been recipients of prestigious research fellowships awarded by Japan Foundation, Mombusho (Ministry of Education, Government of Japan), Saburo Okita Memorial Fellowship, Nippon Foundation, Korea Foundation, Nehru Memorial Fellowship, and Fellowship from the Chinese and Taiwanese Governments. Besides, students from Japan receive fellowship from the Indian Council of Cultural Relations.