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Functional Expression of Transient Receptor Potential Vanilloid Channels (TRPV) in T cells And Macrophages: Their Implications in Immune Regulations and infection

Functional Expression of Transient Receptor Potential Vanilloid Channels (TRPV) in T cells And Macrophages: Their Implications in Immune Regulations and infection

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Functional Expression of Transient Receptor Potential Vanilloid Channels (TRPV) in T cells And Macrophages: Their Implications in Immune Regulations and infection
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<strong>SPECIAL CENTRE FOR MOLECULAR MEDICINE JAWAHARLAL NEHRU UNIVERSITY</strong> <strong>SPEAKER: DR. CHANDAN GOSWAMI </strong> School of Biology, National Institute of Science Education and Research, Institute of Physics Campus, Sachivalaya Marg, Bhubaneswar, Orissa: Email: chandan@niser.ac.in <strong>TALK TITLE: Functional Expression of Transient Receptor Potential Vanilloid Channels (TRPV) in T cells And Macrophages: Their Implications in Immune Regulations and infection</strong> <strong>ABSTRACT: </strong>The importance of Ca2+-signaling and temperature in the context of T cell activation is well known. However, the molecular identities of key players involved in such critical regulations are still unknown. In this work we explored the endogenous expression of Transient Receptor Potential Vanilloid channels, a group of thermosensitive and non-selective cation channels, in T cells. Using flowcytometry and confocal microscopy, we demonstrate that members belonging to TRPV subfamily are expressed endogenously in the human T cell line Jurkat, in primary human T cells and in primary murine splenic T cells. We also demonstrate that TRPV1- and TRPV4-specific agonists namely RTX and 4?PDD can cause Ca2+-influx in T cells. Moreover, our results show that expression of these channels could be up-regulated in T cells during ConA-driven mitogenic activation of T cells. By specific blocking of TRPV1 and TRPV4 channels, we found that these TRPV inhibitors may regulate T cell activation and effector cytokine(s) production by suppressing TNF, IL-2 and IFN? release. These results may have broad implication in the context of cell-mediated immunity, especially T cell responses and their regulations, neuro-immune interactions and molecular understanding of channelopathies. In addition to T-cells, our recent results with macrophages suggest that these channels also play an important role in macrophage functions and can be the key targets for several infections. <strong>DAY : Monday, 1st June'2015</strong>

A warm welcome to the modified and updated website of the Centre for East Asian Studies. The East Asian region has been at the forefront of several path-breaking changes since 1970s beginning with the redefining the development architecture with its State-led development model besides emerging as a major region in the global politics and a key hub of the sophisticated technologies. The Centre is one of the thirteen Centres of the School of International Studies, Jawaharlal Nehru University, New Delhi that provides a holistic understanding of the region.

Initially, established as a Centre for Chinese and Japanese Studies, it subsequently grew to include Korean Studies as well. At present there are eight faculty members in the Centre. Several distinguished faculty who have now retired include the late Prof. Gargi Dutt, Prof. P.A.N. Murthy, Prof. G.P. Deshpande, Dr. Nranarayan Das, Prof. R.R. Krishnan and Prof. K.V. Kesavan. Besides, Dr. Madhu Bhalla served at the Centre in Chinese Studies Programme during 1994-2006. In addition, Ms. Kamlesh Jain and Dr. M. M. Kunju served the Centre as the Documentation Officers in Chinese and Japanese Studies respectively.

The academic curriculum covers both modern and contemporary facets of East Asia as each scholar specializes in an area of his/her interest in the region. The integrated course involves two semesters of classes at the M. Phil programme and a dissertation for the M. Phil and a thesis for Ph. D programme respectively. The central objective is to impart an interdisciplinary knowledge and understanding of history, foreign policy, government and politics, society and culture and political economy of the respective areas. Students can explore new and emerging themes such as East Asian regionalism, the evolving East Asian Community, the rise of China, resurgence of Japan and the prospects for reunification of the Korean peninsula. Additionally, the Centre lays great emphasis on the building of language skills. The background of scholars includes mostly from the social science disciplines; History, Political Science, Economics, Sociology, International Relations and language.

Several students of the centre have been recipients of prestigious research fellowships awarded by Japan Foundation, Mombusho (Ministry of Education, Government of Japan), Saburo Okita Memorial Fellowship, Nippon Foundation, Korea Foundation, Nehru Memorial Fellowship, and Fellowship from the Chinese and Taiwanese Governments. Besides, students from Japan receive fellowship from the Indian Council of Cultural Relations.